Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
NLRP3 inflammasome—a key player in antiviral responses
C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Inflammasomes and pyroptosis as therapeutic targets for COVID-19
The inflammatory response to severe acute respiratory syndrome–related coronavirus 2
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …
RIG-I and other RNA sensors in antiviral immunity
Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
Discriminating self from non-self in nucleic acid sensing
Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …
molecular patterns that are characteristic of the pathogens, including receptors that are …
Post-translational modification control of innate immunity
J Liu, C Qian, X Cao - Immunity, 2016 - cell.com
A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
Initiation and perpetuation of NLRP 3 inflammasome activation and assembly
EI Elliott, FS Sutterwala - Immunological reviews, 2015 - Wiley Online Library
The NLRP 3 (NOD‐like receptor family, pyrin domain containing 3) inflammasome is a
multiprotein complex that orchestrates innate immune responses to infection and cell stress …
multiprotein complex that orchestrates innate immune responses to infection and cell stress …