In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

Background The role of trypanocidal therapy in patients with established Chagas'
cardiomyopathy is unproven. Methods We conducted a prospective, multicenter …

This paper aims to review the applications of the polymerase chain reaction (PCR) for the
detection and identification of trypanosomes in animals. The diagnosis of trypanosomes …

This report of a WHO Expert Committee reviews current knowledge of Chagas disease and
its pathogenesis discusses the causative parasite the triatomine vectors and the natural …

Background: Benznidazole is recommended for treatment of Chagas infection. Effects of
combination therapy with benznidazole and posaconazole have not been tested in …

Background: Obesity is associated with increased cardiovascular morbidity and mortality. A
direct effect of isolated obesity on cardiac function is not well established. Objective: To …

Background The analytical validation of sensitive, accurate and standardized Real-Time
PCR methods for Trypanosoma cruzi quantification is crucial to provide a reliable laboratory …

Immunoblotting with trypomastigote excreted-secreted antigens (TESA blot) of Trypanosoma
cruzi was evaluated as a method for diagnosis of chronic and acute phases as well as …

Background. We conducted a study of congenital Trypanosoma cruzi infection in Santa
Cruz, Bolivia. Our objective was to apply new tools to identify weak points in current …

Quantitative real-time PCR (qPCR) is an accurate method to quantify Trypanosoma cruzi
DNA and can be used to follow-up parasitemia in Chagas disease (CD) patients undergoing …