Neurodevelopmental disorders—the history and future of a diagnostic concept
This article describes the history of the diagnostic class of neurodevelopmental disorders
(NDDs) up to DSM-5. We further analyze how the development of genetics will transform the …
(NDDs) up to DSM-5. We further analyze how the development of genetics will transform the …
Myelination-independent functions of oligodendrocyte precursor cells in health and disease
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …
Most genetic risk for autism resides with common variation
A key component of genetic architecture is the allelic spectrum influencing trait variability.
For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is …
For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is …
Casting a wide net: role of perineuronal nets in neural plasticity
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …
neurons in the CNS during development and control plasticity in the adult CNS. They appear …
Sex differences in autism spectrum disorders
Sex differences in autism spectrum disorders : Current Opinion in Neurology Sex differences in
autism spectrum disorders : Current Opinion in Neurology Log in or Register Subscribe to …
autism spectrum disorders : Current Opinion in Neurology Log in or Register Subscribe to …
Maternal immune activation and neuropsychiatric illness: a translational research perspective
AS Brown, U Meyer - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24. 32 and a significant overlap with schizophrenia
Molecular autism, 2017 - Springer
Background Over the past decade genome-wide association studies (GWAS) have been
applied to aid in the understanding of the biology of traits. The success of this approach is …
applied to aid in the understanding of the biology of traits. The success of this approach is …
Genetics and epigenetics of autism spectrum disorder—current evidence in the field
B Wiśniowiecka-Kowalnik, BA Nowakowska - Journal of applied genetics, 2019 - Springer
Autism spectrum disorders (ASD) is a heterogenous group of neurodevelopmental disorders
characterized by problems in social interaction and communication as well as the presence …
characterized by problems in social interaction and communication as well as the presence …
SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)
New technologies enabling genome-wide interrogation have led to a large and rapidly
growing number of autism spectrum disorder (ASD) candidate genes. Although …
growing number of autism spectrum disorder (ASD) candidate genes. Although …
Gene hunting in autism spectrum disorder: on the path to precision medicine
DH Geschwind - The Lancet Neurology, 2015 - thelancet.com
Autism spectrum disorder is typical of the majority of neuropsychiatric syndromes in that it is
defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this …
defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this …