Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

While the application of cryogenic electron microscopy (cryo-EM) to helical polymers in
biology has a long history, due to the huge number of helical macromolecular assemblies in …

Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a
major obstacle for clinical application of iPSCs, requires novel approaches for selectively …

Peptide self-assembly is a hierarchical process during which secondary structures formed in
the initial stages play a critical role in determining the subsequent assembling processes …

Coiled-coil 'bundlemer'peptides were selectively modified with allyloxycarbonyl (alloc)-
protected lysine, a non-natural amino acid containing an alkene on its side chain. The …

The development of peptide-based materials has emerged as one of the most challenging
aspects of biomaterials in recent years. It has been widely acknowledged that peptide-based …

The rational design of linear peptides that assemble controllably and predictably in water is
challenging. Short sequences must encode unique target structures and avoid alternative …

Although it is well-known proteins and their complexes are hierarchically organized and
highly ordered structures, it remains a major challenge to replicate their hierarchical self …