Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …

It has been proposed that the hypothalamus helps to control ageing, but the mechanisms
responsible remain unclear. Here we develop several mouse models in which hypothalamic …

One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where
the data only captures a small fraction of the transcriptome of each cell. Almost all …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

Neurogenesis, a process of generation of new neurons, is reported to be reduced in several
neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …