The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Hyaluronic acid (HA), also named hyaluronan, is an omnipresent component of the tissue
microenvironment. It is extensively used to formulate targeted drug delivery systems for …

Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies …

Pancreatic ductal adenocarcinoma (PDAC) remains the most deadly disease worldwide,
with the lowest survival rate among all cancer types. Recent evidence suggests that …

The hyaluronan (HA) matrix in the tissue microenvironment is crucial for maintaining
homeostasis by regulating inflammatory signalling, endothelial–mesenchymal transition and …

Hyaluronic acid or hyaluronan (HA) is perhaps one of the most uncomplicated large
polymers that regulates several normal physiological processes and, at the same time …

Accumulation of hyaluronan (HA) in pericellular stroma and carcinoma cells is predictive of
unfavorable patient prognosis in many epithelial cancers. However, it is not known whether …

The understanding of the role of hyaluronan in physiology and various pathological
conditions has changed since the complex nature of its synthesis, degradation and …

Hyaluronan (HA) accumulation in clear cell renal cell carcinoma (ccRCC) is associated with
poor prognosis; however, its biology and role in tumorigenesis are unknown. RNA …

A hypoxic microenvironment plays important roles in the progression of solid tumors,
including oral squamous cell carcinoma (OSCC). Long noncoding RNAs (lncRNAs) have …