Precision‐cut lung slices: a powerful ex vivo model to investigate respiratory infectious diseases
Respiratory infections are a leading cause of mortality worldwide. Most of the research on
the underlying disease mechanisms is based on cell culture, organoid, or surrogate animal …
the underlying disease mechanisms is based on cell culture, organoid, or surrogate animal …
[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …
effects, making it the preferred means of drug delivery for the treatment of respiratory …
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
CM Zimmermann, D Baldassi, K Chan… - Journal of Controlled …, 2022 - Elsevier
While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …
Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage
C Beck, D Ramanujam, P Vaccarello… - Nature …, 2023 - nature.com
Recent studies of severe acute inflammatory lung disease including COVID-19 identify
macrophages to drive pulmonary hyperinflammation and long-term damage such as fibrosis …
macrophages to drive pulmonary hyperinflammation and long-term damage such as fibrosis …
Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes
SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical
urgency. siRNA-based therapies are a promising strategy to fight viral infections. By …
urgency. siRNA-based therapies are a promising strategy to fight viral infections. By …
Applications and approaches for three-dimensional precision-cut lung slices. Disease modeling and drug discovery
Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial
lung disease, and lung cancer, are among the leading causes of morbidity globally and …
lung disease, and lung cancer, are among the leading causes of morbidity globally and …
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …
economic burden, which fueled the development of treatment strategies and vaccines at an …
Post-COVID Syndrome: The Research Progress in the Treatment of Pulmonary sequelae after COVID-19 Infection
Post-COVID syndrome or long COVID is defined as the persistence of symptoms after
confirmed SARS-CoV-2 infection, the pathogen responsible for coronavirus disease. The …
confirmed SARS-CoV-2 infection, the pathogen responsible for coronavirus disease. The …