Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the …

In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

The harsh microenvironment of ductal carcinoma in situ (DCIS) exerts strong evolutionary
selection pressures on cancer cells. We hypothesize that the poor metabolic conditions near …

Cancer growth can be described as a caricature of the renewal process of the tissue of
origin, where the tissue architecture has a strong influence on the evolutionary dynamics …

The field of melt electrowriting (MEW) has seen significant progress, bringing innovative
advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for …

Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and
response to treatment of different cancer cell lines. Their popularity is largely due to the …

Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …

Over the past 25 years, there has been an unparalleled increase in understanding of cancer
biology. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to …

The initiation and progression of cancers reflect the underlying process of somatic evolution,
in which the diversification of heritable phenotypes provides a substrate for natural selection …

Background Adaptive therapy aims to tackle cancer drug resistance by leveraging resource
competition between drug-sensitive and resistant cells. Here, we present a theoretical study …