Role of environmental contaminants in the etiology of Alzheimer's disease: a review

M Yegambaram, B Manivannan… - Current Alzheimer …, 2015 - ingentaconnect.com
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70%
risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include …

The role of metallobiology and amyloid‐β peptides in Alzheimer's disease

BR Roberts, TM Ryan, AI Bush… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120 (Suppl. 1), 149–166. Abstract The biggest risk factor for
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …

Exposure to low-dose ambient fine particulate matter PM2.5 and Alzheimer's disease, non-Alzheimer's dementia, and Parkinson's disease in North Carolina

SH Rhew, J Kravchenko, HK Lyerly - PloS one, 2021 - journals.plos.org
Alzheimer's disease (AD), non-AD dementia, and Parkinson's disease (PD) are increasingly
common in older adults, yet all risk factors for their onset are not fully understood …

Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated …

TH Lu, TJ Tseng, CC Su, FC Tang, CC Yen, YY Liu… - Toxicology letters, 2014 - Elsevier
Abstract Arsenic (As), a well-known high toxic metal, is an important environmental and
industrial contaminant, and it induces oxidative stress, which causes many adverse health …

Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: Role of oxidative stress and inflammatory responses

C Escudero-Lourdes - Neurotoxicology, 2016 - Elsevier
Arsenic (As) is a worldwide naturally occurring metalloid. Human chronic exposure to
inorganic As compounds (iAs), which are at the top of hazardous substances (ATSDR …

Counteracting arsenic toxicity: curcumin to the rescue?

A Bahrami, T Sathyapalan, SA Moallem… - Journal of Hazardous …, 2020 - Elsevier
Arsenicosis leads to various irreversible damages in several organs and is considered to be
a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between …

Lipid integration in neurodegeneration: an overview of Alzheimer's disease

RS Yadav, NK Tiwari - Molecular neurobiology, 2014 - Springer
Various types of lipids and their metabolic products associated with the biological
membrane play a crucial role in signal transduction, modulation, and activation of receptors …

Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability

L Baum, IHS Chan, SKK Cheung, WB Goggins, V Mok… - Biometals, 2010 - Springer
Zinc, copper, and iron aggregate Aβ and accumulate in Alzheimer's disease (AD) plaques.
Some metals are increased in AD vs. control serum. The authors examined levels of 12 …

Attenuation of arsenic neurotoxicity by curcumin in rats

RS Yadav, ML Sankhwar, RK Shukla… - Toxicology and applied …, 2009 - Elsevier
In view of continued exposure to arsenic and associated human health risk including
neurotoxicity, neuroprotective efficacy of curcumin, a polyphenolic antioxidant, has been …

Environmental toxins and Alzheimer's disease progression

M Vasefi, E Ghaboolian-Zare, H Abedelwahab… - Neurochemistry …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia, which causes progressive
memory loss and cognitive decline. Effective strategies to treat or prevent remains one of the …