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When physics takes over: BAR proteins and membrane curvature
Cell membranes become highly curved during membrane trafficking, cytokinesis, infection,
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …
Recent developments in membrane curvature sensing and induction by proteins
Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …
to different local membrane curvatures, and these attributes are conserved across species …
IRSp53 senses negative membrane curvature and phase separates along membrane tubules
BAR domain proteins contribute to membrane deformation in diverse cellular processes.
The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the …
The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the …
Membrane curvature induces cardiolipin sorting
E Beltrán-Heredia, FC Tsai… - Communications …, 2019 - nature.com
Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of
bacteria and in the mitochondrial cristae. This specific localization has been argued to be …
bacteria and in the mitochondrial cristae. This specific localization has been argued to be …
Membrane shape modulates transmembrane protein distribution
Although membrane shape varies greatly throughout the cell, the contribution of membrane
curvature to transmembrane protein targeting is unknown because of the numerous sorting …
curvature to transmembrane protein targeting is unknown because of the numerous sorting …
Protein-induced membrane curvature alters local membrane tension
Adsorption of proteins onto membranes can alter the local membrane curvature. This
phenomenon has been observed in biological processes such as endocytosis, tubulation …
phenomenon has been observed in biological processes such as endocytosis, tubulation …
Bending lipid membranes: experiments after W. Helfrich's model
Current description of biomembrane mechanics originates for a large part from W. Helfrich's
model. Based on his continuum theory, many experiments have been performed in the past …
model. Based on his continuum theory, many experiments have been performed in the past …
Steric pressure between membrane-bound proteins opposes lipid phase separation
CS Scheve, PA Gonzales, N Momin… - Journal of the …, 2013 - ACS Publications
Cellular membranes are densely crowded with a diverse population of integral and
membrane-associated proteins. In this complex environment, lipid rafts, which are phase …
membrane-associated proteins. In this complex environment, lipid rafts, which are phase …
Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins
Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …
Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins
The function of biological membranes is controlled by the interaction of the fluid lipid bilayer
with various proteins, some of which induce or react to curvature. These proteins can …
with various proteins, some of which induce or react to curvature. These proteins can …