When physics takes over: BAR proteins and membrane curvature

M Simunovic, GA Voth, A Callan-Jones… - Trends in cell …, 2015 - cell.com
Cell membranes become highly curved during membrane trafficking, cytokinesis, infection,
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …

Recent developments in membrane curvature sensing and induction by proteins

C Has, SL Das - Biochimica et Biophysica Acta (BBA)-General Subjects, 2021 - Elsevier
Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

C Prévost, H Zhao, J Manzi, E Lemichez… - Nature …, 2015 - nature.com
BAR domain proteins contribute to membrane deformation in diverse cellular processes.
The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the …

Membrane curvature induces cardiolipin sorting

E Beltrán-Heredia, FC Tsai… - Communications …, 2019 - nature.com
Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of
bacteria and in the mitochondrial cristae. This specific localization has been argued to be …

Membrane shape modulates transmembrane protein distribution

S Aimon, A Callan-Jones, A Berthaud, M Pinot… - Developmental cell, 2014 - cell.com
Although membrane shape varies greatly throughout the cell, the contribution of membrane
curvature to transmembrane protein targeting is unknown because of the numerous sorting …

Protein-induced membrane curvature alters local membrane tension

P Rangamani, KK Mandadap, G Oster - Biophysical journal, 2014 - cell.com
Adsorption of proteins onto membranes can alter the local membrane curvature. This
phenomenon has been observed in biological processes such as endocytosis, tubulation …

Bending lipid membranes: experiments after W. Helfrich's model

P Bassereau, B Sorre, A Lévy - Advances in colloid and interface science, 2014 - Elsevier
Current description of biomembrane mechanics originates for a large part from W. Helfrich's
model. Based on his continuum theory, many experiments have been performed in the past …

Steric pressure between membrane-bound proteins opposes lipid phase separation

CS Scheve, PA Gonzales, N Momin… - Journal of the …, 2013 - ACS Publications
Cellular membranes are densely crowded with a diverse population of integral and
membrane-associated proteins. In this complex environment, lipid rafts, which are phase …

Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins

N Ramakrishnan, PBS Kumar, R Radhakrishnan - Physics reports, 2014 - Elsevier
Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins

C Tozzi, N Walani, M Arroyo - New journal of physics, 2019 - iopscience.iop.org
The function of biological membranes is controlled by the interaction of the fluid lipid bilayer
with various proteins, some of which induce or react to curvature. These proteins can …