Neuronal reward and decision signals: from theories to data

W Schultz - Physiological reviews, 2015 - journals.physiology.org
Rewards are crucial objects that induce learning, approach behavior, choices, and
emotions. Whereas emotions are difficult to investigate in animals, the learning function is …

Medial and orbital frontal cortex in decision-making and flexible behavior

MC Klein-Flügge, A Bongioanni, MFS Rushworth - Neuron, 2022 - cell.com
The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of
investigations of decision-making, behavioral flexibility, and social behavior. We review …

A hierarchy of intrinsic timescales across primate cortex

JD Murray, A Bernacchia, DJ Freedman, R Romo… - Nature …, 2014 - nature.com
Specialization and hierarchy are organizing principles for primate cortex, yet there is little
direct evidence for how cortical areas are specialized in the temporal domain. We measured …

The neural basis of reversal learning: An updated perspective

A Izquierdo, JL Brigman, AK Radke, PH Rudebeck… - Neuroscience, 2017 - Elsevier
Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

Value, search, persistence and model updating in anterior cingulate cortex

N Kolling, MK Wittmann, TEJ Behrens… - Nature …, 2016 - nature.com
Dorsal anterior cingulate cortex (dACC) carries a wealth of value-related information
necessary for regulating behavioral flexibility and persistence. It signals error and reward …

Taking stock of value in the orbitofrontal cortex

EB Knudsen, JD Wallis - Nature Reviews Neuroscience, 2022 - nature.com
People with damage to the orbitofrontal cortex (OFC) have specific problems making
decisions, whereas their other cognitive functions are spared. Neurophysiological studies …

Value dynamics affect choice preparation during decision-making

ZZ Balewski, TW Elston, EB Knudsen, JD Wallis - Nature neuroscience, 2023 - nature.com
During decision-making, neurons in the orbitofrontal cortex (OFC) sequentially represent the
value of each option in turn, but it is unclear how these dynamics are translated into a choice …

Orbitofrontal cortex: a neural circuit for economic decisions

C Padoa-Schioppa, KE Conen - Neuron, 2017 - cell.com
Economic choice behavior entails the computation and comparison of subjective values. A
central contribution of neuroeconomics has been to show that subjective values are …

Decoding subjective decisions from orbitofrontal cortex

EL Rich, JD Wallis - Nature neuroscience, 2016 - nature.com
When making a subjective choice, the brain must compute a value for each option and
compare those values to make a decision. The orbitofrontal cortex (OFC) is critically involved …

[HTML][HTML] The orbitofrontal oracle: cortical mechanisms for the prediction and evaluation of specific behavioral outcomes

PH Rudebeck, EA Murray - Neuron, 2014 - cell.com
The orbitofrontal cortex (OFC) has long been associated with the flexible control of behavior
and concepts such as behavioral inhibition, self-control, and emotional regulation. These …