Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Human genetics research has discovered thousands of proteins associated with complex
and rare diseases. Genome-wide association studies (GWAS) and studies of Mendelian …

After decades of discovery, inherited variations have been identified in approximately 20
genes that affect about 80 medications and are actionable in the clinic. And some …

Background Variability in genes implicated in drug pharmacokinetics or drug response can
modulate treatment efficacy or predispose to adverse drug reactions. Besides common …

Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …

Abstract Background A 12-week, double-blind, parallel, multi-center randomized controlled
trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate …

Background Medication-related adverse events, or adverse drug reactions (ADRs) are
harmful events caused by medication. ADRs could have profound effects on the patients' …

Purpose In this study we characterized the genetic variability of 146 clinically relevant genes
influencing drug pharmacokinetics in African and European subpopulations, which are key …

In recent decades, very few new psychiatric drugs have entered the market. Thus,
improvement in the use of antidepressant and antipsychotic therapy has to focus mainly on …

This article provides nomenclature recommendations developed by an international
workgroup to increase transparency and standardization of pharmacogenetic (PGx) result …