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B cell depletion therapies in autoimmune disease: advances and mechanistic insights
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
Extrafollicular responses in humans and SLE
Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …
TLR7 gain-of-function genetic variation causes human lupus
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling
as a mechanism of human systemic autoimmune disease,,,,,–, evidence of lupus-causing …
as a mechanism of human systemic autoimmune disease,,,,,–, evidence of lupus-causing …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
TLR7 escapes X chromosome inactivation in immune cells
M Souyris, C Cenac, P Azar, D Daviaud, A Canivet… - Science …, 2018 - science.org
Toll-like receptor 7 (TLR7) is critical to the induction of antiviral immunity, but TLR7 dosage
is also a key pathogenic factor in systemic lupus erythematosus (SLE), an autoimmune …
is also a key pathogenic factor in systemic lupus erythematosus (SLE), an autoimmune …
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo… - Science …, 2021 - science.org
Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …
Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity
Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus
(SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease …
(SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease …
Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants
The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …
autoimmunity through aggregation of findings from genome-wide association studies …
Immunogenicity of In Vitro-Transcribed RNA
Conspectus In vitro-transcribed RNAs are emerging as new biologics for therapeutic
innovation, as exemplified by their application recently in SARS-CoV-2 vaccinations. RNAs …
innovation, as exemplified by their application recently in SARS-CoV-2 vaccinations. RNAs …
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …