Over the past several decades, extensive research into the Gag polyprotein, the main
structural protein of HIV-1 and all other retroviruses, has changed the way that we describe …

HIV-1 nucleocapsid protein (NC) is a small basic protein generated by the cleavage of the
Gag structural polyprotein precusor by the viral protease during virus assembly in the …

HIV-1 Gag drives a number of events during the genesis of virions and is the only viral
protein required for the assembly of virus-like particles in vitro and in cells. Although a …

Although the human immunodeficiency virus type 1 lipid envelope has been reported to be
enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the …

Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …

Human immunodeficiency virus (HIV) assembly at an infected cell's plasma membrane
requires membrane deformation to organize the near-spherical shape of an immature virus …

The HIV-1 structural protein Gag associates with two types of plasma membrane
microdomains, lipid rafts and tetraspanin-enriched microdomains (TEMs), both of which …

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered.
Studies on HTLV-1 have been instrumental for our understanding of the molecular …

Advances in cell biology and biophysics revealed that cellular membranes consist of
multiple microdomains with specific sets of components such as lipid rafts and TEMs …

The cell plasma membrane is mainly composed of phospholipids, cholesterol and
embedded proteins, presenting a complex interface with the environment. It maintains a …