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DNA G-quadruplex structures: more than simple roadblocks to transcription?
It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …
gene promoters was first linked to the regulation of gene expression. Since then, the …
RNA contributions to the form and function of biomolecular condensates
Biomolecular condensation partitions cellular contents and has important roles in stress
responses, maintaining homeostasis, development and disease. Many nuclear and …
responses, maintaining homeostasis, development and disease. Many nuclear and …
Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
RNAs undergo phase transitions with lower critical solution temperatures
Co-phase separation of RNAs and RNA-binding proteins drives the biogenesis of
ribonucleoprotein granules. RNAs can also undergo phase transitions in the absence of …
ribonucleoprotein granules. RNAs can also undergo phase transitions in the absence of …
RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
Mechanisms and regulation of RNA condensation in RNP granule formation
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
G-Quadruplexes in RNA biology: recent advances and future directions
RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression
mechanisms, from transcription to protein synthesis, and DNA-related processes. Their …
mechanisms, from transcription to protein synthesis, and DNA-related processes. Their …
Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation
RNA-binding proteins are central for many biological processes and their characterization
has demonstrated a broad range of functions as well as a wide spectrum of target structures …
has demonstrated a broad range of functions as well as a wide spectrum of target structures …
RNA G-quadruplexes and stress: emerging mechanisms and functions
RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich
sequences that are found in different regions of RNA molecules. These structures have been …
sequences that are found in different regions of RNA molecules. These structures have been …
Rock, scissors, paper: How RNA structure informs function
RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …