The journey from melanocytes to melanoma
PP Centeno, V Pavet, R Marais - Nature Reviews Cancer, 2023 - nature.com
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …
whose composition changes as a function of an animal's physiological state. Ciliated …
Landscape of enhancer disruption and functional screen in melanoma cells
Z Wang, M Luo, Q Liang, K Zhao, Y Hu, W Wang… - Genome Biology, 2023 - Springer
Background The high mutation rate throughout the entire melanoma genome presents a
major challenge in stratifying true driver events from the background mutations. Numerous …
major challenge in stratifying true driver events from the background mutations. Numerous …
METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway
L Ma, X Zhou, S Yao, X Zhang, J Mao, B Vona… - Cell Death & …, 2024 - nature.com
Craniofacial malformations, often associated with syndromes, are prevalent birth defects.
Emerging evidence underscores the importance of m6A modifications in various …
Emerging evidence underscores the importance of m6A modifications in various …
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Spatiotemporal patterns of gene expression underlie embryogenesis. Despite progress in
single-cell genomics, map** these patterns across whole embryos with comprehensive …
single-cell genomics, map** these patterns across whole embryos with comprehensive …
[HTML][HTML] Identifying in vivo genetic dependencies of melanocyte and melanoma development
S Perlee, Y Ma, MV Hunter, JB Swanson, Z Ming, J ** accessible chromatin across time scales can give insights into its dynamic nature,
for example during cellular differentiation and tissue or organism development. Analysis of …
for example during cellular differentiation and tissue or organism development. Analysis of …
Transcriptional profile and chromatin accessibility in zebrafish melanocytes and melanoma tumors
Transcriptional and epigenetic characterization of melanocytes and melanoma cells isolated
from their in vivo context promises to unveil key differences between these developmentally …
from their in vivo context promises to unveil key differences between these developmentally …
The sclerotome is the source of the dorsal and anal fin skeleton and its expansion is required for median fin development
R Bailon-Zambrano, MK Keating, EC Sales… - …, 2024 - journals.biologists.com
Paired locomotion appendages are hypothesized to have redeployed the developmental
program of median appendages, such as the dorsal and anal fins. Compared with paired …
program of median appendages, such as the dorsal and anal fins. Compared with paired …
[HTML][HTML] Predicted Configuration and Stability of the ATAD2/SOX10 Complex Using Molecular Dynamics Simulations
S Lehrer, PH Rheinstein - Cancer Diagnosis & Prognosis, 2023 - ncbi.nlm.nih.gov
Background/Aim: ATAD2, a melanoma competence factor, forms a protein complex with
SOX10 that facilitates expression of SOX10 developmental target genes. The complex …
SOX10 that facilitates expression of SOX10 developmental target genes. The complex …