Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Biological cells routinely reconfigure their shape using dynamic signalling and regulatory
networks that direct self-assembly processes in time and space, through molecular …

Uncontrolled growth in a confined space generates mechanical compressive stress within
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …

Aggregation of amyloid-β (Aβ) and Tau protein are hallmarks of Alzheimer's disease (AD),
and according to the Aβ-cascade hypothesis, Aβ is considered toxic for neurons and Tau a …

Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …

The Hippo tumour suppressor pathway is a conserved signalling pathway that controls
organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves …

The precise regulation of cellular behaviors within a confined, crowded intracellular
environment is highly amenable in diagnostics and therapeutics. While synthetic circuitry …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …