Novel functionalized spiro [Indoline-3, 5′-pyrroline]-2, 2′ dione derivatives: synthesis, characterization, drug-likeness, ADME, and anticancer potential
A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
Synthesis, characterization, pharmaceutical evaluation, molecular docking and DFT calculations of a novel drug (E)-5-bromo-3-(phenylimino) indolin-2-one
Herein, one-pot synthesis of (E)-5-bromo-3-(phenylimino) indolin-2-one (5BPI molecule),
density function theory for validation of the synthesized molecule, and biological activities …
density function theory for validation of the synthesized molecule, and biological activities …
Sustainable synthesis of ZnO nanostructures using Ficus religiosa leaf extract with enhanced photocatalytic and antibacterial activity
N Ansari, M Kavish, JA Wagay, Z Khan, AR Khan… - Materials Science and …, 2024 - Elsevier
This study presents a scalable approach to synthesizing zinc oxide (ZnO) nanostructures
(NP's) by utilizing the leaf extract of Ficus religiosa plant. The high performance thin layer …
(NP's) by utilizing the leaf extract of Ficus religiosa plant. The high performance thin layer …
[HTML][HTML] Quantum computational, molecular structure, experimental spectra, and molecular docking studies on (S)-3-benzyl-5-(phenylselanyl)-6-(p-tolyl)-3, 4 …
Abstract The published molecule (S)-3-Benzyl-5-(phenylselanyl)-6-(p-tolyl)-3, 4-
dihydropyran-2-one (3B6PL) was selected for the identification of anticancer properties, and …
dihydropyran-2-one (3B6PL) was selected for the identification of anticancer properties, and …
Green synthesis of zinc oxide marigold shaped clusters using Eucalyptus globulus leaf extract as robust photocatalyst for dyes degradation under sunlight
This paper reports a facile route to synthesis of zinc oxide (ZnO) nanoparticles assembled
into marigold shaped clusters utilizing the Eucalyptus globulus leaf extract. Synthesized ZnO …
into marigold shaped clusters utilizing the Eucalyptus globulus leaf extract. Synthesized ZnO …
Solvent solute interaction (IEFPCM model), Michael addition-based anticancer drug synthesis, FTIR, NMR, and UV–visible investigations of spirooxindole …
P Manikandan, M Kumar, P Swarnamughi… - Journal of Molecular …, 2024 - Elsevier
Herein, click chemistry was chosen to synthesize 2AIPC using Knoevenegel and Michael
addition reactions. In this synthesis, Lewis base was attracted by the generation of sp 3 …
addition reactions. In this synthesis, Lewis base was attracted by the generation of sp 3 …
Synthesis of highly functionalized imine-containing halogen-substituted-1-oxo-acenaphthenes and their quantum computational investigation as propitious drugs for …
Herein, the one-keto protected and one-keto transformed into the imine-functionalized Schiff
bases (7a–b) through the 1, 2-dimethoxy-1, 2-dihydroacenaphthylene using calcium oxo …
bases (7a–b) through the 1, 2-dimethoxy-1, 2-dihydroacenaphthylene using calcium oxo …
Design, Synthesis, in vitro Anti‐inflammatory Activity and in silico Studies of Imidazole‐Based 1, 2, 3‐Triazole Hybrids Targeting p38 MAP Kinase
A Awasthi, M Azizur Rahman, D **ili… - …, 2024 - Wiley Online Library
Abstract p38 MAP kinases are involved in numerous inflammatory diseases. A series of 14
molecules of 1, 2, 3 triazole linked 4‐((2‐cyclohexyl‐4, 5‐diphenyl‐1H‐imidazol‐1‐yl) …
molecules of 1, 2, 3 triazole linked 4‐((2‐cyclohexyl‐4, 5‐diphenyl‐1H‐imidazol‐1‐yl) …
Visible-light-mediated O–H functionalization reactions of acetylenic alcohols with 3-diazooxindoles: Facile access to spirooxindole-fused oxacycles
L Xu, J Wang, H Li, H **e, M Qian, Y Hou, S Zhao… - Tetrahedron, 2024 - Elsevier
Visible-light-mediated O–H functionalization reactions of acetylenic alcohols with 3-
diazooxindoles were first described. Various substituted acetylenic alcohols were well …
diazooxindoles were first described. Various substituted acetylenic alcohols were well …
Novel Spirooxindole–Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2‐p53 Interaction
We synthesized a novel compound library featuring a spirooxindole core structure combined
with various heterocycles, including benzofuran, benzothiophene, and thiophene scaffolds …
with various heterocycles, including benzofuran, benzothiophene, and thiophene scaffolds …