[HTML][HTML] The involvement of descending pain inhibitory system in electroacupuncture-induced analgesia
Q Lv, F Wu, X Gan, X Yang, L Zhou, J Chen… - Frontiers in integrative …, 2019 - frontiersin.org
Chronic pain is a major health problem, which would impair life quality and reduce
productivity. Electroacupuncture (EA), a modality of medicine based on the theories of …
productivity. Electroacupuncture (EA), a modality of medicine based on the theories of …
Role of nociceptin/orphanin FQ-NOP receptor system in the regulation of stress-related disorders
M Ubaldi, N Cannella, AM Borruto, M Petrella… - International Journal of …, 2021 - mdpi.com
Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin
opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence …
opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence …
Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse
Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …
Nociceptin receptor-related agonists as safe and non-addictive analgesics
As clinical use of currently available opioid analgesics is often impeded by dose-limiting
adverse effects, such as abuse liability and respiratory depression, new approaches have …
adverse effects, such as abuse liability and respiratory depression, new approaches have …
[HTML][HTML] Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: relevance for novel therapeutics
B Coutens, SL Ingram - Neuropharmacology, 2023 - Elsevier
Opioid receptors are G protein-coupled receptors (GPCRs) that regulate activity within
peripheral, subcortical and cortical circuits involved in pain, reward, and aversion …
peripheral, subcortical and cortical circuits involved in pain, reward, and aversion …
Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABAB receptor-mediated mechanism
M Petrella, AM Borruto, L Curti, A Domi, E Domi, L Xu… - …, 2024 - Elsevier
Abstract The Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly
expressed within several regions of the mesolimbic system, including the ventral tegmental …
expressed within several regions of the mesolimbic system, including the ventral tegmental …
Potential therapeutic targets for the treatment of opioid abuse and pain
Although μ-opioid peptide (MOP) receptor agonists are effective analgesics available in
clinical settings, their serious adverse effects put limits on their use. The marked increase in …
clinical settings, their serious adverse effects put limits on their use. The marked increase in …
Cellular mechanisms for antinociception produced by oxytocin and orexins in the rat spinal lamina II—Comparison with those of other endogenous pain modulators
E Kumamoto - Pharmaceuticals, 2019 - mdpi.com
Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and
B, inhibit nociceptive transmission in the rat spinal dorsal horn. In order to unveil cellular …
B, inhibit nociceptive transmission in the rat spinal dorsal horn. In order to unveil cellular …
Nociceptin/orphanin FQ peptide receptor mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat
E Seseña, E Soto, J Bueno… - Journal of …, 2020 - journals.physiology.org
The vestibular system is modulated by various neuromodulators including opioid peptides.
The current study was conducted to determine whether activation of nociceptin/orphanin FQ …
The current study was conducted to determine whether activation of nociceptin/orphanin FQ …
Pharmacology of Calcium Channel
S Mallik, PC Acharya - Frontiers in Pharmacology of Neurotransmitters, 2020 - Springer
Calcium channel plays a very crucial role in the regulation of various vital functions of the
body. The effects and modes of action of various drugs on calcium channels have been …
body. The effects and modes of action of various drugs on calcium channels have been …