Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains
difficult and AF-related complications cause unacceptable morbidity and mortality even on …

Atrial dysfunction has been widely considered a marker or consequence of other cardiac
conditions rather than the cause itself. Here, we propose the term atrial failure as a clinically …

The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …

Introduction Stroke is one of the leading causes of mortality and morbidity globally. Atrial
fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic …

Importance Understanding the temporal association between atrial fibrillation (AF) and
ischemic stroke informs our understanding of the AF-stroke mechanism and treatment of …

Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

The cellular and molecular mechanism involved in the pathogenesis of atrial fibrosis are
highly complex. We have reviewed the literature that covers the effectors, signal transduction …

Atrial fibrillation (AF), the commonest arrhythmia, shows associations with various disease
conditions. Mounting evidence indicates that atrial fibrosis is an important part of the …