Reproducibility in science: improving the standard for basic and preclinical research

CG Begley, JPA Ioannidis - Circulation research, 2015 - Am Heart Assoc
Medical and scientific advances are predicated on new knowledge that is robust and
reliable and that serves as a solid foundation on which further advances can be built. In …

Analysis of drug combinations: current methodological landscape

J Foucquier, M Guedj - Pharmacology research & perspectives, 2015 - Wiley Online Library
Combination therapies exploit the chances for better efficacy, decreased toxicity, and
reduced development of drug resistance and owing to these advantages, have become a …

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

N Percie du Sert, V Hurst, A Ahluwalia… - Journal of Cerebral …, 2020 - journals.sagepub.com
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

[HTML][HTML] Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

NP Du Sert, A Ahluwalia, S Alam, MT Avey… - PLoS …, 2020 - journals.plos.org
Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

[HTML][HTML] Experimental design and analysis and their reporting: new guidance for publication in BJP

MJ Curtis, RA Bond, D Spina, A Ahluwalia… - British journal of …, 2015 - ncbi.nlm.nih.gov
This editorial is part of a series describing changes in the guidelines for authors making
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); …

Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies

KK Tsilidis, JC Kasimis, DS Lopez, EE Ntzani… - Bmj, 2015 - bmj.com
Objectives To summarise the evidence and evaluate the validity of the associations between
type 2 diabetes and the risk of develo** or dying from cancer. Design An umbrella review …

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

L Belbasis, V Bellou, E Evangelou… - The Lancet …, 2015 - thelancet.com
Background The cause of multiple sclerosis is believed to involve environmental exposure
and genetic susceptibility. We aimed to summarise the environmental risk factors that have …

The mass production of redundant, misleading, and conflicted systematic reviews and meta‐analyses

JPA Ioannidis - The Milbank Quarterly, 2016 - Wiley Online Library
Policy Points: Currently, there is massive production of unnecessary, misleading, and
conflicted systematic reviews and meta‐analyses. Instead of promoting evidence‐based …

Adiposity and cancer at major anatomical sites: umbrella review of the literature

M Kyrgiou, I Kalliala, G Markozannes, MJ Gunter… - Bmj, 2017 - bmj.com
Objective To evaluate the strength and validity of the evidence for the association between
adiposity and risk of develo** or dying from cancer. Design Umbrella review of systematic …

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

E Theodoratou, I Tzoulaki, L Zgaga, JPA Ioannidis - Bmj, 2014 - bmj.com
Objective To evaluate the breadth, validity, and presence of biases of the associations of
vitamin D with diverse outcomes. Design Umbrella review of the evidence across systematic …