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Aptamer-based detection of circulating targets for precision medicine
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
Discovery of aptamers targeting the receptor-binding domain of the SARS-CoV-2 spike glycoprotein
Y Song, J Song, X Wei, M Huang, M Sun… - Analytical …, 2020 - ACS Publications
The World Health Organization has declared the outbreak of a novel coronavirus (SARS-
CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the …
CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the …
Cancer biomarker detection: recent achievements and challenges
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …
a great deal of effort has been devoted to the exploration of new technologies to detect early …
The design of reversible hydrogels to capture extracellular matrix dynamics
The extracellular matrix (ECM) is a dynamic environment that constantly provides physical
and chemical cues to embedded cells. Much progress has been made in engineering …
and chemical cues to embedded cells. Much progress has been made in engineering …
Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
C Wei, C Yang, S Wang, D Shi, C Zhang, X Lin, Q Liu… - Molecular cancer, 2019 - Springer
Abstract Background Tumor-associated macrophages (TAMs) are major components of
tumor microenvironment that frequently associated with tumor metastasis in human cancers …
tumor microenvironment that frequently associated with tumor metastasis in human cancers …
Replacing antibodies with aptamers in lateral flow immunoassay
Aptamers have been identified against various targets as a type of chemical or nucleic acid
ligand by systematic evolution of ligands by exponential enrichment (SELEX) with high …
ligand by systematic evolution of ligands by exponential enrichment (SELEX) with high …
Point-of-care biosensor-based diagnosis of COVID-19 holds promise to combat current and future pandemics
Efficient and rapid detection of viruses plays an extremely important role in disease
prevention, diagnosis, and environmental monitoring. Early screening of viral infection …
prevention, diagnosis, and environmental monitoring. Early screening of viral infection …
Bioinspired engineering of a multivalent aptamer‐functionalized nanointerface to enhance the capture and release of circulating tumor cells
Circulating tumor cell (CTC)‐enrichment by using aptamers has a number of advantages,
but the issue of compromised binding affinities and stabilities in real samples hinders its …
but the issue of compromised binding affinities and stabilities in real samples hinders its …
EMT‐cancer cells‐derived exosomal miR‐27b‐3p promotes circulating tumour cells‐mediated metastasis by modulating vascular permeability in colorectal cancer
Background Metastasis is the main cause of death in colorectal cancer (CRC). Circulating
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …