Understanding the mechanisms that control chromosome folding in the nucleus of
eukaryotes and their contribution to gene regulation is a key open issue in molecular …

Chromosome structure and dynamics are essential for life, as the way that our genomes are
spatially organized within cells is crucial for gene expression, differentiation, and genome …

Gene expression states influence the 3D conformation of the genome through poorly
understood mechanisms. Here, we investigate the conformation of the murine HoxB locus, a …

How chromosomes fold into 3D structures and how genome functions are affected or even
controlled by their spatial organization remain challenging questions. Hi-C experiment has …

New Hi-C technologies have revealed that chromosomes have a complex network of spatial
contacts in the cell nucleus of higher organisms, whose organisation is only partially …

Here we present a pneumatically-actuated nanofluidic platform that has the capability of
dynamically controlling the confinement environment of macromolecules in solution. Using a …

In recent years interest has grown on the applications of polymer physics to model chromatin
folding in order to try to make sense of the complexity of experimental data emerging from …

As revealed by novel technologies, chromosomes in the nucleus of mammalian cells have a
complex spatial organization that serves vital functional purposes. Here we use models from …

A statistical model describing a fine structure of the intra-chromosome maps obtained by a
genome-wide chromosome conformation capture method (Hi–C) is proposed. The model …

Understanding the mechanisms that control the organization of chromosomes in the space
of the nucleus of cells, and its contribution to gene regulation, is a key open issue in …