Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as
oligodendrocytes both myelinate and provide metabolic support to axons. In multiple …

Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …

The study of brain plasticity has tended to focus on the synapse, where well-described
activity-dependent mechanisms are known to play a key role in learning and memory …

Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the develo** central nervous system (CNS) …

The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2+
cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous …

Functional screening for compounds that promote remyelination represents a major hurdle
in the development of rational therapeutics for multiple sclerosis. Screening for …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …