Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study
Objective To compare the risk of mortality among people with opioid use disorder on and off
opioid agonist treatment (OAT) in a setting with a high prevalence of illicitly manufactured …
opioid agonist treatment (OAT) in a setting with a high prevalence of illicitly manufactured …
Endogenous opiates and behavior: 2019
RJ Bodnar - Peptides, 2021 - Elsevier
This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …
research concerning the endogenous opioid system, summarizing articles published during …
Protracted renal clearance of fentanyl in persons with opioid use disorder
Introduction The illicit opioid supply in the US is increasingly adulterated with fentanyl. As
such, persons with opioid use disorder (OUD) may be regularly exposed to fentanyl …
such, persons with opioid use disorder (OUD) may be regularly exposed to fentanyl …
Method for successfully inducting individuals who use illicit fentanyl onto buprenorphine/naloxone
Background and Objectives Individuals exposed to fentanyl are at risk of precipitated
withdrawal using typical buprenorphine/naloxone induction procedures. Methods This case …
withdrawal using typical buprenorphine/naloxone induction procedures. Methods This case …
Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated
Opioid-related fatalities involving synthetic opioids have reached unprecedented levels. This
study evaluated the respiratory depressant effects of seven fentanyl analogs that have either …
study evaluated the respiratory depressant effects of seven fentanyl analogs that have either …
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression
Opioid overdoses, particularly those involving fentanyl-related substances (FRS), present a
significant public health challenge in the United States. This structure-activity relationship …
significant public health challenge in the United States. This structure-activity relationship …
Technology-assisted methadone take-home dosing for dispensing methadone to persons with opioid use disorder during the Covid-19 pandemic
Introduction Covid-19 confers substantial risk for the> 400,000 patients who receive
methadone for the treatment of opioid use disorder (OUD) and methods for safely …
methadone for the treatment of opioid use disorder (OUD) and methods for safely …
Buprenorphine exposure levels to optimize treatment outcomes in opioid use disorder
The severity of the ongoing opioid crisis, recently exacerbated by the COVID-19 pandemic,
emphasizes the importance for individuals suffering from opioid use disorder (OUD) to have …
emphasizes the importance for individuals suffering from opioid use disorder (OUD) to have …
[PDF][PDF] Fentanyl: Clinical Applications and Pharmacological Considerations
I Karunarathna - Uva Clinical Lab. Retrieved from Fentanyl …, 2024 - researchgate.net
With its remarkable analgesic potency, often 50 to 100 times greater than morphine, fentanyl
presents a valuable tool in addressing acute and chronic pain, as well as in providing …
presents a valuable tool in addressing acute and chronic pain, as well as in providing …
Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: a placebo-controlled crossover study in healthy volunteers …
LM Moss, MH Algera, R Dobbins, F Gray, S Strafford… - PLoS …, 2022 - journals.plos.org
Background Opioid-induced respiratory depression driven by ligand binding to mu-opioid
receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist …
receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist …