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Systems genetics approaches to understand complex traits
Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …
that underlies complex traits. It uses a range of experimental and statistical methods to …
The genetics of quantitative traits: challenges and prospects
A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus map** and …
quantitative traits. We review the principles of quantitative trait locus map** and …
Comparison of RNA-Seq and microarray in transcriptome profiling of activated T cells
To demonstrate the benefits of RNA-Seq over microarray in transcriptome profiling, both
RNA-Seq and microarray analyses were performed on RNA samples from a human T cell …
RNA-Seq and microarray analyses were performed on RNA samples from a human T cell …
RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays
Ultra-high-throughput sequencing is emerging as an attractive alternative to microarrays for
genoty**, analysis of methylation patterns, and identification of transcription factor binding …
genoty**, analysis of methylation patterns, and identification of transcription factor binding …
Systems genetics of complex traits in Drosophila melanogaster
Determining the genetic architecture of complex traits is challenging because phenotypic
variation arises from interactions between multiple, environmentally sensitive alleles. We …
variation arises from interactions between multiple, environmentally sensitive alleles. We …
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by
factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we …
factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we …
Advantages of RNA‐seq compared to RNA microarrays for transcriptome profiling of anterior cruciate ligament tears
Microarrays and RNA‐seq are at the forefront of high throughput transcriptome analyses.
Since these methodologies are based on different principles, there are concerns about the …
Since these methodologies are based on different principles, there are concerns about the …
Harnessing naturally randomized transcription to infer regulatory relationships among genes
We develop an approach utilizing randomized genotypes to rigorously infer causal
regulatory relationships among genes at the transcriptional level, based on experiments in …
regulatory relationships among genes at the transcriptional level, based on experiments in …
The influence of genetic variation on gene expression
The view that changes to the control of gene expression rather than alterations to protein
sequence are central to the evolution of organisms has become something of a truism in …
sequence are central to the evolution of organisms has become something of a truism in …
Effects of cocaine, nicotine, and marijuana exposure in Drosophila melanogaster development: a systematic review and meta-analysis
Abuse-related drug usage is a public health issue. Drosophila melanogaster has been used
as an animal model to study the biological effects of these psychoactive substances in …
as an animal model to study the biological effects of these psychoactive substances in …