RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …

Atomic resolution structures are now available for more than 20 complexes of proteins with
specific RNAs. This review examines two main themes that appear in this set of structures. A …

MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to
silence mRNA expression. Argonaute binding alters the properties of an RNA guide …

A hallmark of RNA interference is the production of short double-stranded RNA (dsRNA)
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …

The yeast splicing factor BBP (branchpoint bridging protein) interacts directly with pre-mRNA
at or very near the highly conserved branchpoint sequence UACUAAC within the …

RNAi-mediated silencing of specific genes is a promising strategy for gene therapy. To
utilize RNAi for therapy, an efficient and safe method for delivery of RNA into the cell cytosol …

▪ Abstract The ribonucleoprotein (RNP) domain is one of the most common eukaryotic
protein folds. Proteins containing RNP domains function in important steps of …

MANY proteins involved in pre mRNA processing contain one or more copies of a 70–90-
amino-acid αβ module called the ribo-nucleoprotein domain1–4. RNA maturation depends …

Human, mouse, and Xenopus mRNAs encoding the Ul snRNP-specific UlA protein contain a
conserved 47 nt region in their 3'untranslated regions (UTRs). In vitro studies show that …

We demonstrate that a bacteriophage protein and a spliceosomal protein can be converted
into eukaryotic translational repressor proteins. mRNAs with binding sites for the …