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Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis
The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
Allicin and cancer hallmarks
WH Talib, MM Baban, AO Azzam, JJ Issa, AY Ali… - Molecules, 2024 - mdpi.com
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in
the discovery and development of new therapeutic agents owing to their biologically active …
the discovery and development of new therapeutic agents owing to their biologically active …
Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors
Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …
[HTML][HTML] Elucidation of interleukin-19 as a therapeutic target for breast cancer by computational analysis and experimental validation
Abstract Interleukin 19 (IL-19) is a cytokine produced by monocytes and belongs to the
family of IL-10. The IL-19 protein stimulates fibronectin (FN) expression and assembly …
family of IL-10. The IL-19 protein stimulates fibronectin (FN) expression and assembly …
[HTML][HTML] Clinicopathological Significance and Expression pattern of Bcl2 in Breast Cancer: A comprehensive in silico and in vitro Study
B-cell lymphoma/leukemia gene-2 (Bcl-2) is the primary proto-oncogene that has been
shown to work by preventing apoptosis/programmed cell death. Bcl-2 combines a variety of …
shown to work by preventing apoptosis/programmed cell death. Bcl-2 combines a variety of …
Targeting p53 misfolding conundrum by stabilizing agents and their analogs in breast cancer therapy: a comprehensive computational analysis
Cancer continues to be a major global public health concern and one of the foremost causes
of death. Delays in the diagnosis and cure may cause an increase in advanced stage …
of death. Delays in the diagnosis and cure may cause an increase in advanced stage …
[HTML][HTML] A comprehensive analysis of notch signaling genes in breast cancer: expression pattern and prognostic significance
The most recurrent type of cancer among women is breast cancer which is an intricate
disease with high intertumoral and intratumoral heterogeneity. Such variability is a key factor …
disease with high intertumoral and intratumoral heterogeneity. Such variability is a key factor …
Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
[HTML][HTML] Mechanistic elucidation of Juglanthraquinone C targeting breast cancer: a network pharmacology-based investigation
Breast cancer is the leading cause of death among women worldwide. Despite the recent
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …
Targeting triple negative breast cancer stem cells using nanocarriers
Breast cancer is a complex and heterogeneous disease, encompassing various subtypes
characterized by distinct molecular features, clinical behaviors, and treatment responses …
characterized by distinct molecular features, clinical behaviors, and treatment responses …