Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis

H Qayoom, S Sofi, MA Mir - Immunologic research, 2023 - Springer
The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …

Allicin and cancer hallmarks

WH Talib, MM Baban, AO Azzam, JJ Issa, AY Ali… - Molecules, 2024 - mdpi.com
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in
the discovery and development of new therapeutic agents owing to their biologically active …

Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

S Sofi, U Mehraj, H Qayoom, S Aisha, A Almilaibary… - Medical Oncology, 2022 - Springer
Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …

[HTML][HTML] Elucidation of interleukin-19 as a therapeutic target for breast cancer by computational analysis and experimental validation

N Jan, H Qayoom, M Alkhanani, A Almilaibary… - Saudi Journal of …, 2023 - Elsevier
Abstract Interleukin 19 (IL-19) is a cytokine produced by monocytes and belongs to the
family of IL-10. The IL-19 protein stimulates fibronectin (FN) expression and assembly …

[HTML][HTML] Clinicopathological Significance and Expression pattern of Bcl2 in Breast Cancer: A comprehensive in silico and in vitro Study

U Mehraj, N Jan, A Almilaibary, I Ahmad… - Saudi Journal of …, 2024 - Elsevier
B-cell lymphoma/leukemia gene-2 (Bcl-2) is the primary proto-oncogene that has been
shown to work by preventing apoptosis/programmed cell death. Bcl-2 combines a variety of …

Targeting p53 misfolding conundrum by stabilizing agents and their analogs in breast cancer therapy: a comprehensive computational analysis

BU Haq, H Qayoom, S Sofi, N Jan, A Shabir… - Frontiers in …, 2024 - frontiersin.org
Cancer continues to be a major global public health concern and one of the foremost causes
of death. Delays in the diagnosis and cure may cause an increase in advanced stage …

[HTML][HTML] A comprehensive analysis of notch signaling genes in breast cancer: expression pattern and prognostic significance

S Sofi, H Qayoom, N Jan, N Khaliq… - Advances in cancer …, 2023 - Elsevier
The most recurrent type of cancer among women is breast cancer which is an intricate
disease with high intertumoral and intratumoral heterogeneity. Such variability is a key factor …

Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology

N Jan, S Sofi, H Qayoom, A Shabir, BU Haq, MA Macha… - Heliyon, 2024 - cell.com
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …

[HTML][HTML] Mechanistic elucidation of Juglanthraquinone C targeting breast cancer: a network pharmacology-based investigation

H Qayoom, M Alkhanani, A Almilaibary… - Saudi Journal of …, 2023 - Elsevier
Breast cancer is the leading cause of death among women worldwide. Despite the recent
treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming …

Targeting triple negative breast cancer stem cells using nanocarriers

N Dasari, GS Guntuku, SKSS Pindiprolu - Discover Nano, 2024 - Springer
Breast cancer is a complex and heterogeneous disease, encompassing various subtypes
characterized by distinct molecular features, clinical behaviors, and treatment responses …