Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Alzheimer's disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …