Abstract Context Although prostate cancer (PCa) screening reduces the incidence of
advanced disease and mortality, trade-offs include overdiagnosis and resultant …

Radiotherapy (RT) is a key component of the management of older cancer patients. Level I
evidence in older patients is limited. The International Society of Geriatric Oncology (SIOG) …

Prostate cancer is the second most common cancer in men worldwide and causes over
250,000 deaths each year. Overtreatment of indolent disease also results in significant …

Primary prostate cancer is the most common malignancy in men but has highly variable
outcomes, highlighting the need for biomarkers to determine which patients can be …

Background Active surveillance (AS) has been proposed as an effective strategy to reduce
overtreatment among men with lower risk prostate cancers. However, historical rates of …

Chinese translation Background: Accurate estimation of life expectancy is essential to
offering appropriate care to men with early-stage prostate cancer, but mortality risks …

Many newly diagnosed prostate cancers present as low Gleason score tumors that require
no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal …

Background and Purpose Intensity modulated radiation therapy (IMRT) can deliver higher
doses with less damage of healthy tissues compared with three-dimensional radiation …

Purpose: Prior studies have reported the underuse of deferred treatment (ie active
surveillance or watchful waiting) for low risk prostate cancer in the United States. We …

Importance Up-front treatment of older men with low-risk prostate cancer can cause
morbidity without clear survival benefit; however, most such patients receive treatment …