Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions

ES Rudge, AHY Chan, FJ Leeper - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

A Ullah, K Shah Bukhari, S Khan, F Farooq… - …, 2023 - Wiley Online Library
Pyrimidine derivatives have attracted much attention in medicinal chemistry because of their
diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura …

Synthesis of pyrimidine ligand and its mononuclear metal (II)/(III) complexes: Spectroscopic characterization, thermal, DFT, molecular docking, antimicrobial and …

AI Hassaballah, AK El-Ziaty, EF Ewies… - Inorganic Chemistry …, 2023 - Elsevier
Mononuclear complexes of the type [M (L) 2 (H 2 O) 2] Cl 2 (where M= Co (II), Ni (II), Mn (II),
Zn (II), Cu (II) and Cd (II)) and [Fe (L) 2 (H 2 O) 2] Cl 3 have been prepared and …

[HTML][HTML] Identification of the furanose ring conformations and the factors driving their adoption

D Walczak, A Sikorski, D Grzywacz, A Nowacki… - Carbohydrate …, 2023 - Elsevier
Three groups of furanoses with restricted freedom of rotation on the C3–C4, C2–C3, and C1–
C2 bonds, respectively, are presented. Conformational analysis of these furanoses is …

Diversification and design of novel aniline‐pyrimidines via sonogashira/suzuki cross coupling reactions catalyzed by Novel CLPN‐Pd

A Ullah, J Liu, AU Khan, QU Khan, F Guo… - …, 2021 - Wiley Online Library
Aniline‐pyrimidines derivatives, especially Mepanipyrim are used as fungicides and
obliging to control several diseases, particularly grey mould (Botrytis cinerea) of vegetables …

Characteristic 1 H NMR spectra of β-d-ribofuranosides and ribonucleosides: factors driving furanose ring conformations

D Walczak, A Sikorski, D Grzywacz, A Nowacki… - RSC …, 2022 - pubs.rsc.org
A series of β-D-ribofuranosides and ribonucleosides fused with 2, 3-O-isopropylidene ring
was synthesized and studied in terms of their conformational preferences. Based on the 1H …

Discovery of 5′-Substituted 5-Fluoro-2′-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors

M Dasari, SC Pelly, J Geng, HB Gold… - ACS Pharmacology & …, 2023 - ACS Publications
5-Fluorouracil and 5-fluorouracil-based prodrugs have been used clinically for decades to
treat cancer. Their anticancer effects are most prominently ascribed to inhibition of …

Synthesis and Antiviral Evaluation of 2′, 3′-β-C-Disubstituted Nucleoside Analogue ProTides to Test a Conformational Model of Potency Against Hepatitis C

ZW Dentmon, CJ Butch, HB Gold, DC Liotta - Synlett, 2023 - thieme-connect.com
An analysis of nucleoside active metabolite potencies against Hepatitis C virus (HCV)
versus their parent ground-state energetic conformational bias as calculated by density …

Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions

FJ Leeper, ES Rudge, AHY Chan - 2022 - repository.cam.ac.uk
Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …