Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions
ES Rudge, AHY Chan, FJ Leeper - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …
containing molecules and their more stable bisphosphonate analogues have the potential to …
Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives
A Ullah, K Shah Bukhari, S Khan, F Farooq… - …, 2023 - Wiley Online Library
Pyrimidine derivatives have attracted much attention in medicinal chemistry because of their
diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura …
diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura …
Synthesis of pyrimidine ligand and its mononuclear metal (II)/(III) complexes: Spectroscopic characterization, thermal, DFT, molecular docking, antimicrobial and …
AI Hassaballah, AK El-Ziaty, EF Ewies… - Inorganic Chemistry …, 2023 - Elsevier
Mononuclear complexes of the type [M (L) 2 (H 2 O) 2] Cl 2 (where M= Co (II), Ni (II), Mn (II),
Zn (II), Cu (II) and Cd (II)) and [Fe (L) 2 (H 2 O) 2] Cl 3 have been prepared and …
Zn (II), Cu (II) and Cd (II)) and [Fe (L) 2 (H 2 O) 2] Cl 3 have been prepared and …
[HTML][HTML] Identification of the furanose ring conformations and the factors driving their adoption
Three groups of furanoses with restricted freedom of rotation on the C3–C4, C2–C3, and C1–
C2 bonds, respectively, are presented. Conformational analysis of these furanoses is …
C2 bonds, respectively, are presented. Conformational analysis of these furanoses is …
Diversification and design of novel aniline‐pyrimidines via sonogashira/suzuki cross coupling reactions catalyzed by Novel CLPN‐Pd
Aniline‐pyrimidines derivatives, especially Mepanipyrim are used as fungicides and
obliging to control several diseases, particularly grey mould (Botrytis cinerea) of vegetables …
obliging to control several diseases, particularly grey mould (Botrytis cinerea) of vegetables …
Characteristic 1 H NMR spectra of β-d-ribofuranosides and ribonucleosides: factors driving furanose ring conformations
A series of β-D-ribofuranosides and ribonucleosides fused with 2, 3-O-isopropylidene ring
was synthesized and studied in terms of their conformational preferences. Based on the 1H …
was synthesized and studied in terms of their conformational preferences. Based on the 1H …
Discovery of 5′-Substituted 5-Fluoro-2′-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors
5-Fluorouracil and 5-fluorouracil-based prodrugs have been used clinically for decades to
treat cancer. Their anticancer effects are most prominently ascribed to inhibition of …
treat cancer. Their anticancer effects are most prominently ascribed to inhibition of …
Synthesis and Antiviral Evaluation of 2′, 3′-β-C-Disubstituted Nucleoside Analogue ProTides to Test a Conformational Model of Potency Against Hepatitis C
An analysis of nucleoside active metabolite potencies against Hepatitis C virus (HCV)
versus their parent ground-state energetic conformational bias as calculated by density …
versus their parent ground-state energetic conformational bias as calculated by density …
Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions
FJ Leeper, ES Rudge, AHY Chan - 2022 - repository.cam.ac.uk
Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …
containing molecules and their more stable bisphosphonate analogues have the potential to …