Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …

DNA nanostructures have been demonstrated as promising carriers for gene delivery. In the
carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is …

Small-molecule prodrugs have become the main toolbox to improve the unfavorable
physicochemical properties of potential therapeutic compounds in contemporary anti-cancer …

Sequential control of exogenous chemical events inside cells is a promising way to regulate
cell functions and fate. Herein we report a DNA nanocomplex containing cascade …

Owing to the specific and high binding affinity of aptamers to their targets, aptamer–drug
conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer …

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to
activate the Fenton reaction or Fenton-like reaction to generate strong oxidative hydroxyl …

Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-
infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense …