Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes

F Zatterale, M Longo, J Naderi, GA Raciti… - Frontiers in …, 2020 - frontiersin.org
Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

[HTML][HTML] Free fatty acid receptors in health and disease

I Kimura, A Ichimura, R Ohue-Kitano… - Physiological …, 2019 - journals.physiology.org
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

G Wang, J Li, L Bojmar, H Chen, Z Li, GC Tobias, M Hu… - Nature, 2023 - nature.com
Cancer alters the function of multiple organs beyond those targeted by metastasis,. Here we
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …

[HTML][HTML] The carbohydrate-insulin model: a physiological perspective on the obesity pandemic

DS Ludwig, LJ Aronne, A Astrup, R de Cabo… - The American journal of …, 2021 - Elsevier
According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …

Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models

DS Ludwig, CM Apovian, LJ Aronne, A Astrup… - European journal of …, 2022 - nature.com
The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Linking gut microbiota and inflammation to obesity and insulin resistance

MJA Saad, A Santos, PO Prada - Physiology, 2016 - journals.physiology.org
Obesity and insulin resistance are the major predisposing factors to comorbidities, such as
Type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative …

Anti-inflammatory nutrients and obesity-associated metabolic-inflammation: state of the art and future direction

G Grosso, D Laudisio, E Frias-Toral, L Barrea… - Nutrients, 2022 - mdpi.com
Growing evidence supports the hypothesis that dietary factors may play a role in systemic
low-grade chronic inflammation. Summary evidence from randomized controlled trials has …

Diet and inflammation in cognitive ageing and Alzheimer's disease

AM McGrattan, B McGuinness, MC McKinley… - Current nutrition …, 2019 - Springer
Abstract Purpose of Review Nutrition is known to modulate the immune system and may
alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …