Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Neural tissue engineering: strategies for repair and regeneration

CE Schmidt, JB Leach - Annual review of biomedical …, 2003 - annualreviews.org
▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury

KD Anderson, JD Guest, WD Dietrich… - Journal of …, 2017 - liebertpub.com
The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

A systematic review of cellular transplantation therapies for spinal cord injury

W Tetzlaff, EB Okon, S Karimi-Abdolrezaee… - Journal of …, 2011 - liebertpub.com
Cell transplantation therapies have become a major focus in pre-clinical research as a
promising strategy for the treatment of spinal cord injury (SCI). In this article, we …

Concepts and methods for the study of axonal regeneration in the CNS

MH Tuszynski, O Steward - Neuron, 2012 - cell.com
Progress in the field of axonal regeneration research has been like the process of axonal
growth itself: there is steady progress toward reaching the target, but there are episodes of …

Combinatorial therapies after spinal cord injury: how can biomaterials help?

T Führmann, PN Anandakumaran… - Advanced healthcare …, 2017 - Wiley Online Library
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats

O Rapalino, O Lazarov-Spiegler, E Agranov… - Nature medicine, 1998 - nature.com
Postinjury recovery in most tissues requires an effective dialog with macrophages; however,
in the mammalian central nervous system, this dialog may be restricted (possibly due to its …

Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells

Y Li, PM Field, G Raisman - Science, 1997 - science.org
The upper cervical corticospinal tract was transected on one side in adult rats. A suspension
of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site …