Tuberculosis drug discovery: challenges and new horizons

GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Recent advancements in deciphering the therapeutic properties of plant secondary metabolites: phenolics, terpenes, and alkaloids

B Hilal, MM Khan, Q Fariduddin - Plant Physiology and Biochemistry, 2024 - Elsevier
Plants produce a diverse range of secondary metabolites that serve as defense compounds
against a wide range of biotic and abiotic stresses. In addition, their potential curative …

[HTML][HTML] Anticancer potential of selected flavonols: Fisetin, kaempferol, and quercetin on head and neck cancers

R Kubina, M Iriti, A Kabała-Dzik - Nutrients, 2021 - mdpi.com
Flavonols are ones of the most common phytochemicals found in diets rich in fruit and
vegetables. Research suggests that molecular functions of flavonoids may bring a number of …

An overview of mechanism and chemical inhibitors of shikimate kinase

BK Chagaleti, MBR Reddy, V Saravanan… - Journal of …, 2023 - Taylor & Francis
Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten
causes of death worldwide. Resistance development in the bacteria occurs because of …

Anti-mycobacterial natural products and mechanisms of action

J Han, X Liu, L Zhang, RJ Quinn, Y Feng - Natural product reports, 2022 - pubs.rsc.org
Covering: up to June, 2020 Tuberculosis (TB) continues to be a major disease with high
mortality and morbidity globally. Drug resistance and long duration of treatment make …

Integrated computer-aided drug design and biophysical simulation approaches to determine natural anti-bacterial compounds for Acinetobacter baumannii

RAH Almihyawi, ZT Naman, HMH Al-Hasani… - Scientific reports, 2022 - nature.com
Acinetobacter baumannii is a nosocomial bacterial pathogen and is responsible for a wide
range of diseases including pneumonia, necrotizing fasciitis, meningitis, and sepsis. The …

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

J Yang, L Zhang, W Qiao, Y Luo - MedComm, 2023 - Wiley Online Library
Tuberculosis (TB) remains a significant public health concern in the 21st century, especially
due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) …

[HTML][HTML] Eugenol derivatives containing 1, 2, 3-triazole-chalcone hybrids for shikimate kinase inhibition

B Ardiansah, A Farhan, A Firdaus, T Ariyani… - Journal of Saudi …, 2024 - Elsevier
Eugenol, a primary component of clove oil, is a compound of considerable interest in
medicinal chemistry due to its demonstrated potential as an effective agent in various …

Allostery, engineering and inhibition of tryptophan synthase

RN D'Amico, DD Boehr - Current Opinion in Structural Biology, 2023 - Elsevier
The final two steps of tryptophan biosynthesis are catalyzed by the enzyme tryptophan
synthase (TS), composed of alpha (αTS) and beta (βTS) subunits. Recently, experimental …

Atosiban and Rutin exhibit anti-mycobacterial activity-An integrated computational and biophysical insight toward drug repurposing strategy against Mycobacterium …

R Sharma, SA Muthu, M Agarwal, NK Mehto… - International Journal of …, 2023 - Elsevier
With the advancements of high throughput computational screening procedures, drug
repurposing became the privileged framework for drug discovery. The structure-based drug …