Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

Purpose Tau deposition is a key pathological feature of Alzheimer's disease (AD) and other
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …

The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and
other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here …

Intrinsically disordered proteins (IDPs) play many biological roles in the human proteome
ranging from vesicular transport, signal transduction to neurodegenerative diseases. The Aβ …

Ironically, population aging which is considered a public health success has been
accompanied by a myriad of new health challenges, which include neurodegenerative …

Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD)
and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau …

The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble
intracellular deposits central to the development of Alzheimer's disease (AD) and other …

Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …