The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …

Diabetes mellitus (type 1 and type 2) and the complications associated with this condition
are an urgent public health problem, as the incidence of diabetes mellitus is steadily …

SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple
signaling and disease related pathways with a broad diversity of reported substrates. Here …

There has been a rapid increase in the incidence of diabetes as well the associated
vascular complications. Both genetic and environmental factors have been implicated in …

Using single transcription factors to reprogram cells could produce important insights into
the epigenetic mechanisms that direct normal differentiation, or counter inappropriate …

Epigenetic modifications regulate critical functions that underlie chromosome metabolism.
Understanding the molecular changes to chromatin structure and the functional relationship …

Polycystic ovary syndrome (PCOS) is a common fertility disorder with metabolic sequelae.
Our lab previously characterized reproductive phenotypes in a prenatally androgenized …

We applied peptide array methylation to determine an optimized target sequence for the
SET7/9 (KMT7) protein lysine methyltransferase. Based on this, we identified 91 new …