Oligonucleotide aptamers: new tools for targeted cancer therapy
H Sun, X Zhu, PY Lu, RR Rosato, W Tan… - Molecular Therapy-Nucleic …, 2014 - cell.com
Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …
Chemical modification of aptamers for increased binding affinity in diagnostic applications: Current status and future prospects
JP Elskens, JM Elskens, A Madder - International journal of molecular …, 2020 - mdpi.com
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
The chemical biology of aptamers
G Mayer - Angewandte Chemie International Edition, 2009 - Wiley Online Library
Taking a strand: Aptamers are small single‐stranded oligonucleotides that fold into a well‐
defined 3D structure and interact with high affinity and specificity with their target molecules …
defined 3D structure and interact with high affinity and specificity with their target molecules …
ABCs of DNA aptamer and related assay development
TK Sharma, JG Bruno, A Dhiman - Biotechnology advances, 2017 - Elsevier
This review is intended to guide the novice in aptamer research and development to
understand virtually all of the aptamer development options and currently available assay …
understand virtually all of the aptamer development options and currently available assay …
Aptamers and the next generation of diagnostic reagents
Antibodies have been extensively used as capture and detection reagents in diagnostic
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
Aptamers and their applications in nanomedicine
H Sun, Y Zu - Small, 2015 - Wiley Online Library
Aptamers are composed of short RNA or single‐stranded DNA sequences that, when folded
into their unique 3D conformation, can bind to their targets with high specificity and affinity …
into their unique 3D conformation, can bind to their targets with high specificity and affinity …
A basic insight into aptamer-drug conjugates (ApDCs)
Aptamers are often compared with antibodies since both types of molecules function as
targeting ligands for specific cancer cell recognition. However, aptamers offer several …
targeting ligands for specific cancer cell recognition. However, aptamers offer several …
Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and develo** technologies
The most common form of genetic variation, single nucleotide polymorphisms or SNPs, can
affect the way an individual responds to the environment and modify disease risk. Although …
affect the way an individual responds to the environment and modify disease risk. Although …
Towards XNA nanotechnology: new materials from synthetic genetic polymers
Nucleic acids display remarkable properties beyond information storage and propagation.
The well-understood base pairing rules have enabled nucleic acids to be assembled into …
The well-understood base pairing rules have enabled nucleic acids to be assembled into …
Applications of cancer cell-specific aptamers in targeted delivery of anticancer therapeutic agents
Aptamers are single-stranded oligonucleotides that specifically bind and interact with their
corresponding targets, including proteins and cells, through unique three-dimensional …
corresponding targets, including proteins and cells, through unique three-dimensional …