Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …
representing a highly heterogeneous group of neoplasms that are among the most …
Glioblastoma: pathology, molecular mechanisms and markers
Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …
implement a complex pro-inflammatory response termed the senescence-associated …
Glioma
Gliomas are primary brain tumours that are thought to derive from neuroglial stem or
progenitor cells. On the basis of their histological appearance, they have been traditionally …
progenitor cells. On the basis of their histological appearance, they have been traditionally …
Pilocytic astrocytoma: pathology, molecular mechanisms and markers
Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago.
They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over …
They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over …
Low-grade developmental and epilepsy associated brain tumors: a critical update 2020
RJ Slegers, I Blumcke - Acta neuropathologica communications, 2020 - Springer
Brain tumors represent the second most frequent etiology in patients with focal seizure onset
before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain …
before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain …
Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E …
J Haroche, F Cohen-Aubart, JF Emile… - Blood, The Journal …, 2013 - ashpublications.org
Histiocytoses are rare disorders of unknown origin with highly heterogeneous prognosis.
BRAFV600E gain-of-function mutations have been observed in 57% of cases of Langerhans …
BRAFV600E gain-of-function mutations have been observed in 57% of cases of Langerhans …
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
Craniopharyngiomas are epithelial tumors that typically arise in the suprasellar region of the
brain. Patients experience substantial clinical sequelae from both extension of the tumors …
brain. Patients experience substantial clinical sequelae from both extension of the tumors …
EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection
The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …