[HTML][HTML] Recent advances in the field of single-cell proteomics
The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-
based methods have dominated the field to date, global proteome profiling has also entered …
based methods have dominated the field to date, global proteome profiling has also entered …
The black hole: CAR T cell therapy in AML
E Atilla, K Benabdellah - Cancers, 2023 - mdpi.com
Simple Summary Unlike B cell malignancies, the progress on generating an adoptive T cell
therapy for relapsed/refractory acute myeloid leukemia (AML) remains insufficient. This …
therapy for relapsed/refractory acute myeloid leukemia (AML) remains insufficient. This …
Hierarchical graph learning for protein–protein interaction
Abstract Protein-Protein Interactions (PPIs) are fundamental means of functions and
signalings in biological systems. The massive growth in demand and cost associated with …
signalings in biological systems. The massive growth in demand and cost associated with …
A new genomic framework to categorize pediatric acute myeloid leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …
driver alterations, many of which are underrepresented in the current classification schemas …
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution
Single-cell sequencing has characterized cell state heterogeneity across diverse healthy
and malignant tissues. However, the plasticity or heritability of these cell states remains …
and malignant tissues. However, the plasticity or heritability of these cell states remains …
Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax
Cancer driver mutations often show distinct temporal acquisition patterns, but the biological
basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of …
basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of …
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia
Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs)
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
S Beneyto-Calabuig, AK Merbach, JA Kniffka, M Antes… - Cell Stem Cell, 2023 - cell.com
Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …