O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies
E Karampini, D Doherty, PE Bürgisser, M Garre… - Blood …, 2024 - ashpublications.org
Abstract von Willebrand factor (VWF) undergoes complex posttranslational modification
within endothelial cells (ECs) before secretion. This includes significant N-and O-linked …
within endothelial cells (ECs) before secretion. This includes significant N-and O-linked …
[HTML][HTML] The Highs and Lows of ADAMTS13 Activity
RJ Shaw, ST Abrams, S Badu, CH Toh… - Journal of Clinical …, 2024 - mdpi.com
Severe deficiency of ADAMTS13 (< 10 iu/dL) is diagnostic of thrombotic thrombocytopenic
purpura (TTP) and leads to accumulation of ultra-large vWF multimers, platelet aggregation …
purpura (TTP) and leads to accumulation of ultra-large vWF multimers, platelet aggregation …
Novel functions for VWF beyond hemostasis
Von Willebrand factor (VWF) has long been recognized for its essential role in hemostasis.
However, increasing evidence in recent years has demonstrated important roles for VWF …
However, increasing evidence in recent years has demonstrated important roles for VWF …
Novel functions for Von Willebrand factor
For many years, it has been known that VWF interacts with FVIII, collagen and platelets. In
addition, the key roles played by VWF in regulating normal hemostasis have been well …
addition, the key roles played by VWF in regulating normal hemostasis have been well …