How close are we to storing data in DNA?

JHDB Gervasio, H da Costa Oliveira… - Trends in …, 2024 - cell.com
DNA is an intelligent data storage medium due to its stability and high density. It has been
used by nature for over 3.5 billion years. Compared with traditional methods, DNA offers …

Novel modalities in DNA data storage

CK Lim, S Nirantar, WS Yew, CL Poh - Trends in Biotechnology, 2021 - cell.com
The field of storing information in DNA has expanded exponentially. Most common
modalities involve encoding information from bits into synthesized nucleotides, storage in …

Trellis BMA: Coded trace reconstruction on IDS channels for DNA storage

SR Srinivasavaradhan, S Gopi… - 2021 IEEE …, 2021 - ieeexplore.ieee.org
Sequencing a DNA strand, as part of the read process in DNA storage, produces multiple
noisy copies which can be combined to produce better estimates of the original strand; this …

Cooperative sequence clustering and decoding for DNA storage system with fountain codes

J Jeong, SJ Park, JW Kim, JS No, HH Jeon… - …, 2021 - academic.oup.com
Motivation In DNA storage systems, there are tradeoffs between writing and reading costs.
Increasing the code rate of error-correcting codes may save writing cost, but it will need …

Rewritable two-dimensional DNA-based data storage with machine learning reconstruction

C Pan, SK Tabatabaei, SMH Tabatabaei Yazdi… - Nature …, 2022 - nature.com
DNA-based data storage platforms traditionally encode information only in the nucleotide
sequence of the molecule. Here we report on a two-dimensional molecular data storage …

Improving error-correcting capability in DNA digital storage via soft-decision decoding

L Ding, S Wu, Z Hou, A Li, Y Xu, H Feng… - National Science …, 2024 - academic.oup.com
Error-correcting codes (ECCs) employed in the state-of-the-art DNA digital storage (DDS)
systems suffer from a trade-off between error-correcting capability and the proportion of …

Reducing cost in DNA-based data storage by sequence analysis-aided soft information decoding of variable-length reads

SJ Park, S Kim, J Jeong, A No, JS No, H Park - Bioinformatics, 2023 - academic.oup.com
Motivation DNA-based data storage is one of the most attractive research areas for future
archival storage. However, it faces the problems of high writing and reading costs for …

Multiplexed long-read plasmid validation and analysis using OnRamp

C Mumm, ML Drexel, TL McDonald, AG Diehl… - Genome …, 2023 - genome.cshlp.org
Recombinant plasmid vectors are versatile tools that have facilitated discoveries in
molecular biology, genetics, proteomics, and many other fields. As the enzymatic and …

Sequencing coverage analysis for combinatorial DNA-based storage systems

I Preuss, B Galili, Z Yakhini… - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
This study introduces a novel model for analyzing and determining the required sequencing
coverage in DNA-based data storage, focusing on combinatorial DNA encoding. We seek to …

Concatenated codes for multiple reads of a DNA sequence

I Maarouf, A Lenz, L Welter… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Decoding sequences that stem from multiple transmissions of a codeword over an insertion,
deletion, and substitution channel is a critical component of efficient deoxyribonucleic acid …