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Outer Membrane Vesicles Transmitting blaNDM-1 Mediate the Emergence of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae
B Tang, A Yang, P Liu, Z Wang, Z Jian… - Antimicrobial Agents …, 2023 - journals.asm.org
Dissemination of hypervirulent and carbapenem-resistant Klebsiella pneumoniae (CRKP)
has been reported worldwide, posing a serious threat to antimicrobial therapy and public …
has been reported worldwide, posing a serious threat to antimicrobial therapy and public …
Sulfamoyl heteroarylcarboxylic acids as promising metallo-β-lactamase inhibitors for controlling bacterial carbapenem resistance
Production of metallo-β-lactamases (MBLs), which hydrolyze carbapenems, is a cause of
carbapenem resistance in Enterobacteriaceae. Development of effective inhibitors for MBLs …
carbapenem resistance in Enterobacteriaceae. Development of effective inhibitors for MBLs …
On the offensive: the role of outer membrane vesicles in the successful dissemination of New Delhi metallo-β-lactamase (NDM-1)
The emergence and worldwide dissemination of carbapenemase-producing Gram-negative
bacteria are a major public health threat. Metallo-β-lactamases (MBLs) represent the largest …
bacteria are a major public health threat. Metallo-β-lactamases (MBLs) represent the largest …
Interaction with a phage gene underlie costs of a β-lactamase
HY Lai, TF Cooper - MBio, 2024 - journals.asm.org
The fitness cost of an antibiotic resistance gene (ARG) can differ across host strains, creating
refuges that allow the maintenance of an ARG in the absence of direct selection for its …
refuges that allow the maintenance of an ARG in the absence of direct selection for its …
Specific protein-membrane interactions promote packaging of metallo-β-lactamases into outer membrane vesicles
Outer membrane vesicles (OMVs) act as carriers of bacterial products such as plasmids and
resistance determinants, including metallo-β-lactamases. The lipidated, membrane …
resistance determinants, including metallo-β-lactamases. The lipidated, membrane …
Trade-offs between antibacterial resistance and fitness cost in the production of metallo-β-lactamases by enteric bacteria manifest as sporadic emergence of …
Meropenem is a clinically important antibacterial reserved for treatment of multiresistant
infections. In meropenem-resistant bacteria of the family Enterobacterales, NDM-1 is …
infections. In meropenem-resistant bacteria of the family Enterobacterales, NDM-1 is …
The H-NS regulator plays a role in the stress induced by carbapenemase expression in Acinetobacter baumannii
F Huang, N Fitchett, C Razo-Gutierrez, C Le… - MSphere, 2020 - journals.asm.org
Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the
ability of Gram-negative bacteria to regulate genes associated with virulence, persistence …
ability of Gram-negative bacteria to regulate genes associated with virulence, persistence …
[PDF][PDF] The H-NS regulator plays a role in the stress induced by carbapenemase expression in Acinetobacter baumannii. mSphere 5: e00793-20
F Huang, N Fitchett, C Razo-Gutierrez, C Le, J Martinez… - 2020 - rephip.unr.edu.ar
Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the
ability of Gram-negative bacteria to regulate genes associated with virulence, persistence …
ability of Gram-negative bacteria to regulate genes associated with virulence, persistence …