[HTML][HTML] A spatial human thymus cell atlas mapped to a continuous tissue axis
T cells develop from circulating precursor cells, which enter the thymus and migrate through
specialized subcompartments that support their maturation and selection. In humans, this …
specialized subcompartments that support their maturation and selection. In humans, this …
Rediscovering the human thymus through cutting-edge technologies
Recent technological advances have transformed our understanding of the human thymus.
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …
[HTML][HTML] Rebuilding and rebooting immunity with stem cells
Advances in modern medicine have enabled a rapid increase in lifespan and, consequently,
have highlighted the immune system as a key driver of age-related disease. Immune …
have highlighted the immune system as a key driver of age-related disease. Immune …
Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy
Biological sex is closely associated with the properties and extent of the immune response,
with males and females showing different susceptibilities to diseases and variations in …
with males and females showing different susceptibilities to diseases and variations in …
The Proteostasis of Thymic Stromal Cells in Health and Diseases
T Liu, S **a - The Protein Journal, 2024 - Springer
The thymus is the key immune organ for the development of T cells. Different populations of
thymic stromal cells interact with T cells, thereby controlling the dynamic development of T …
thymic stromal cells interact with T cells, thereby controlling the dynamic development of T …
Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females
H Vantomme, V Quiniou, L Adda, C Jouannet… - bioRxiv, 2025 - biorxiv.org
Women represent about 80% of patients with autoimmune diseases. This may partly result
from sex-based differences in T cell receptor (TCR) selection during thymocyte …
from sex-based differences in T cell receptor (TCR) selection during thymocyte …
[PDF][PDF] A pipeline for discovery-based research on human T cell development: integrating spatial omics and PSC-T cell platforms
L Stankiewicz - 2024 - open.library.ubc.ca
T cells play a critical role in adaptive immunity by recognizing self, versus non-self antigens,
effectively protecting against pathogens and damaged or cancerous body cells. The …
effectively protecting against pathogens and damaged or cancerous body cells. The …