The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Informing immunotherapy with multi-omics driven machine learning

Y Li, X Wu, D Fang, Y Luo - npj Digital Medicine, 2024 - nature.com
Progress in sequencing technologies and clinical experiments has revolutionized
immunotherapy on solid and hematologic malignancies. However, the benefits of …

From genotype to phenotype: Raman spectroscopy and machine learning for label-free single-cell analysis

Y Zhang, K Chang, B Ogunlade, L Herndon… - ACS …, 2024 - ACS Publications
Raman spectroscopy has made significant progress in biosensing and clinical research.
Here, we describe how surface-enhanced Raman spectroscopy (SERS) assisted with …

Novel aspects of Raman spectroscopy in skin research

D Lunter, V Klang, D Kocsis… - Experimental …, 2022 - Wiley Online Library
The analytical technology of Raman spectroscopy has an almost 100‐year history. During
this period, many modifications and developments happened in the method like discovery of …

Absolute quantification of serum exosomes in patients with an sers-lateral flow strip biosensor for noninvasive clinical cancer diagnosis

X Su, Y **e, X Liu, M Chen, C Zheng… - ACS Applied Materials …, 2023 - ACS Publications
Exosomes (exos) widely existing in body fluids show great potential for noninvasive cancer
diagnosis. Quantitative analysis of exos is traditionally performed by targeting specific …

Metabolic response to small molecule therapy in colorectal cancer tracked with Raman spectroscopy and metabolomics

G Cutshaw, N Joshi, X Wen, E Quam… - Angewandte Chemie …, 2024 - Wiley Online Library
Despite numerous screening tools for colorectal cancer (CRC), 25% of patients are
diagnosed with advanced disease. Novel diagnostic technologies that are early, accurate …

Label-free plasmon-enhanced spectroscopic HER2 detection for dynamic therapeutic surveillance of breast cancer

Y **e, Y Wen, X Su, C Zheng, M Li - Analytical Chemistry, 2022 - ACS Publications
The expression of human epidermal growth factor receptor-2 (HER2) has important
implications for pathogenesis, progression, and therapeutic efficacy of breast cancer. The …

Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation

P Anantha, Z Liu, P Raj, I Barman - Biosensors and Bioelectronics, 2023 - Elsevier
White adipose tissue (WAT) and brown adipose tissue (BAT) are the primary types of fats in
humans, and they play prominent roles in energy storage and thermogenesis, respectively …

Rapid, label-free classification of glioblastoma differentiation status combining confocal Raman spectroscopy and machine learning

LM Wurm, B Fischer, V Neuschmelting, D Reinecke… - Analyst, 2023 - pubs.rsc.org
Label-free identification of tumor cells using spectroscopic assays has emerged as a
technological innovation with a proven ability for rapid implementation in clinical care …

Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren's syndrome

X Chen, X Wu, C Chen, C Luo, Y Shi, Z Li, X Lv… - Scientific Reports, 2023 - nature.com
The aim of this study was to explore the feasibility of Raman spectroscopy combined with
computer algorithms in the diagnosis of primary Sjögren syndrome (pSS). In this study …