Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Structures of α-synuclein filaments from human brains with Lewy pathology
Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration
Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic
accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in …
accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in …
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
Structures of α-synuclein filaments from multiple system atrophy
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Novel tau filament fold in corticobasal degeneration
W Zhang, A Tarutani, KL Newell, AG Murzin… - Nature, 2020 - nature.com
Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …
[HTML][HTML] Interaction between Aβ and tau in the pathogenesis of Alzheimer's disease
H Zhang, W Wei, M Zhao, L Ma, X Jiang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular
neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of …
neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of …
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is
associated with repetitive head impacts or exposure to blast waves. First described as punch …
associated with repetitive head impacts or exposure to blast waves. First described as punch …
Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …