Major histocompatibility complex class IIA and IIB genes of Nile tilapia Oreochromis niloticus: genomic structure, molecular polymorphism and expression patterns

J Pang, F Gao, M Lu, X Ye, H Zhu, X Ke - Fish & Shellfish Immunology, 2013 - Elsevier
Major histocompatibility complex (MHC) is a large genomic region characterized by
extremely high polymorphism, and it plays an important role in the immune response of …

Protective cellular and humoral immune responses to Edwardsiella tarda in flounder (Paralichthys olivaceus) immunized by an inactivated vaccine

X Wu, J **ng, X Tang, X Sheng, H Chi, W Zhan - Molecular Immunology, 2022 - Elsevier
Protection is crucial for a vaccine. In this study, flounder was inoculated with an inactivated
Edwardsiella tarda for 5 weeks then challenged with E. tarda, after that, the protective …

The effects of IL-1β, IL-8, G-CSF and TNF-α as molecular adjuvant on the immune response to an E. tarda subunit vaccine in flounder (Paralichthys olivaceus)

M Guo, X Tang, X Sheng, J **ng, W Zhan - Fish & shellfish immunology, 2018 - Elsevier
Cytokines play vital roles in mounting immune responses and activating host defense
network. In this study, the expression plasmid pcDNA3. 1 (pcN3) encoding four flounder …

Edwardsiella tarda Outer Membrane Protein C: An Immunogenic Protein Induces Highly Protective Effects in Flounder (Paralichthys olivaceus) against …

F Liu, X Tang, X Sheng, J **ng, W Zhan - International Journal of …, 2016 - mdpi.com
Outer membrane protein C of Edwardsiella tarda is a major cell surface antigen and it was
identified to be an immunogenic protein by Western blot using flounder (Paralichthys …

MHC class IIα gene polymorphism and its association with resistance/susceptibility to Vibrio anguillarum in Japanese flounder (Paralichthys olivaceus)

T Xu, S Chen, Y Zhang - Developmental & Comparative Immunology, 2010 - Elsevier
Association between polymorphism of the major histocompatibility complex (MHC) genes
and disease resistance has been documented for few teleosts. In this study, we first …

Molecular cloning, genomic structure, polymorphism and expression analysis of major histocompatibility complex class IIA and IIB genes of half-smooth tongue sole …

T Xu, S Chen, X Ji, Z Sha - Fish & Shellfish Immunology, 2009 - Elsevier
Major histocompatibility complex (MHC) genes play an important role in the immune
response of vertebrates. Its function is to present foreign peptide to the T-cell. In order to …

Molecular Identification, Polymorphism, and Expression Analysis of Major Histocompatibility Complex Class IIA and B Genes of Turbot (Scophthalmus maximus)

YX Zhang, SL Chen - Marine biotechnology, 2006 - Springer
Major histocompatibility complex (MHC) class II has a central role in the adaptive immune
system by presenting foreign peptides to the T-cell receptor. The full lengths of MHC class II …

MHC polymorphism and disease resistance to Vibrio anguillarum in 12 selective Japanese flounder (Paralichthys olivaceus) families

T Xu, S Chen, X Ji, Y Tian - Fish & Shellfish Immunology, 2008 - Elsevier
Genetic variation in the major histocompatibility complex (MHC) class IIB was tested in
Japanese flounder (Paralichthys olivaceus) for survival after challenge with bacterial …

Comparative study of the vaccine potential of six outer membrane proteins of Edwardsiella tarda and the immune responses of flounder (Paralichthys olivaceus) after …

F Liu, X Tang, X Sheng, J **ng, W Zhan - Veterinary immunology and …, 2017 - Elsevier
To obtain effective vaccine candidates for Edwardsiella tarda, six outer membrane proteins
(OMPs) of E. tarda were selected and recombinantly expressed. Western blotting analysis …

Characterization of the major histocompatibility complex class II genes in miiuy croaker

T Xu, Y Sun, G Shi, Y Cheng, R Wang - PLoS One, 2011 - journals.plos.org
Major histocompatibility complex (MHC) has a central role in the adaptive immune system by
presenting foreign peptide to the T-cell receptor. In order to study the molecular function and …