As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or …

Importance There is a strong rationale for treating sarcomas with immunotherapy. Objective
To assess the efficacy and safety of programmed cell death protein 1 (PD-1) targeting in …

Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger
human health. Over the past decade, the relationship between microorganisms and human …

Immune checkpoint inhibitors (ICIs) have revolutionized our approach to cancer treatment in
the past decade. While monoclonal antibodies to CTLA‐4 and PD‐1/PD‐L1 have produced …

Abstract Background Soft-tissue sarcomas (STSs) are rare malignancies, accounting for
approximately 1% of adult cancer. Metastatic disease carries a poor prognosis, and various …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …

Immune checkpoint inhibitors (ICIs) are starting to transform the treatment for patients with
advanced cancer. The extensive application of these antibodies for various cancer obtains …