The role of the VEGF family in coronary heart disease
Y Zhou, X Zhu, H Cui, J Shi, G Yuan, S Shi… - Frontiers in …, 2021 - frontiersin.org
The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …
Effects of aging on angiogenesis
J Lähteenvuo, A Rosenzweig - Circulation research, 2012 - Am Heart Assoc
Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …
Gene therapeutic strategies for peripheral artery disease and new opportunities provided by adeno-associated virus vectors
Peripheral artery disease (PAD) is a vascular disorder caused by occlusive atherosclerosis,
which commonly impairs blood flow to the lower extremities. The prevalence of PAD is …
which commonly impairs blood flow to the lower extremities. The prevalence of PAD is …
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
Vascular endothelial growth factors (VEGFs) and their tyrosine kinase receptors (VEGFR-1-
3) are central mediators of angiogenesis and lymphangiogenesis. VEGFR-3 ligands VEGF …
3) are central mediators of angiogenesis and lymphangiogenesis. VEGFR-3 ligands VEGF …
AdVEGF-B186 and AdVEGF-DΔNΔC induce angiogenesis and increase perfusion in porcine myocardium
J Nurro, PJ Halonen, A Kuivanen, M Tarkia, A Saraste… - Heart, 2016 - heart.bmj.com
Objective Coronary heart disease remains a significant clinical problem, and new therapies
are needed especially for patients with refractory angina for whom the current therapies do …
are needed especially for patients with refractory angina for whom the current therapies do …
Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects
S Jauhiainen, SK Häkkinen, PI Toivanen… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—The mature form of human vascular endothelial growth factor-D (hVEGF-
DΔNΔC) is an efficient angiogenic factor, but its full mechanism of action has remained …
DΔNΔC) is an efficient angiogenic factor, but its full mechanism of action has remained …
Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance
Vascular endothelial growth factor-D (VEGF-D) is a secreted glycoprotein that promotes
growth of blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis), and …
growth of blood vessels (angiogenesis) and lymphatic vessels (lymphangiogenesis), and …
Comparison of efficiency and function of vascular endothelial growth factor adenovirus vectors in endothelial cells for gene therapy of placental insufficiency
C Rossi, M Lees, V Mehta, T Heikura, J Martin… - Human Gene …, 2020 - liebertpub.com
Severe fetal growth restriction (FGR) affects 1: 500 pregnancies, is untreatable and causes
serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of …
serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of …
The history of the WHHL rabbit, an animal model of familial hypercholesterolemia (II)-contribution to the development and validation of the therapeutics for …
M Shiomi - Journal of Atherosclerosis and Thrombosis, 2020 - jstage.jst.go.jp
A number of effective drugs have been developed through animal experiments, contributing
to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its …
to the health of many patients. In particular, the WHHL rabbit family (WHHL rabbits and its …
Pro-angiogenic efficacy of transplanting endothelial progenitor cells for treating hindlimb ischemia in hyperglycemic rabbits
Aims To evaluate the effectiveness of endothelial progenitor cells (EPCs) therapy in
ischemia with or without hyperglycemia. Methods Japanese White Rabbits were randomly …
ischemia with or without hyperglycemia. Methods Japanese White Rabbits were randomly …