Cancer is a global issue majorly affecting develo** countries. According to a survey, 63%
of deaths due to cancer are reported from develo** countries. There are different …

Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …

E3 ubiquitin ligases are attractive targets in the ubiquitin–proteasome system, however, the
development of small-molecule ligands has been rewarded with limited success. The von …

Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways,
identification of USP7 inhibitors has attracted considerable interest. Despite substantial …

Protein ubiquitylation is a widespread post-translational modification, regulating cellular
signalling with many outcomes, such as protein degradation, endocytosis, cell cycle …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

The von Hippel–Lindau tumor suppressor protein is the substrate binding subunit of the VHL
E3 ubiquitin ligase, which targets hydroxylated α subunit of hypoxia inducible factors (HIFs) …

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …

The human genome encodes several hundred E3 ubiquitin ligases containing RING
domains, and around 28 containing HECT domains. These enzymes catalyze the transfer of …

Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …